Engineering a potent boron-10-enriched polymeric nanoparticle for boron neutron capture therapy - supporting information

Background: Boron neutron capture therapy (BNCT) is a promising cancer treatment that eliminates

tumor cells by triggering high-energy radiation within cancer cells. Aim: In vivo evaluation of poly(vinyl

alcohol)/boric acid crosslinked nanoparticles (PVA/BA NPs) for BNCT. Materials & methods: PVA/BA NPs

were synthesized and intravenously injected into tumor-bearingmice for BNCT. Results: The in vitro boron

uptake of PVA/BA NPs in tumor cells was 70-fold higher than the required boron uptake for successful

BNCT. In an in vivo study, PVA/BA NPs showed a 44.29% reduction in tumor size compared with clinically

used boronophenylalanine for oral cancer in a murine model. Conclusion: PVA/BA NPs exhibited effective

therapeutic results for oral cancer treatments in BNCT.