Parental occupational &environmental risk factors for childhood bone cancer in Mansoura oncology center: A Case control study

Background: Cancer is the most frequently diagnosed disease-related cause of death among children and adolescents study objectives: This study was conducted to assess parental occupational and environmental risk factors among a sample of Egyptian childhood bone cancer cases. Subject &methods: A retrospective case control study was conducted in Mansoura Oncology center (OCMU). Study groups included bone cancer cases (n=51) and matched control group (n=67). Data collection included demographic data, history of occupational &environmental risk factors such as pesticides, solvents and radiation for children & parents. Results: Consanguinity, exposure to n nitrose compounds through burning incense & environmental tobacco smoke are significantly higher among bone cancer cases (p<0.05). The most common maternal chemical exposure is household cleaning products and organophosphate pesticides exposure for fathers mainly in farming jobs. Paternal risky jobs such as farming, driving and excavation were slightly higher among cases than controls with no significant difference (p>0.05). Conclusion: The current study revealed that consanguinity and environmental tobacco smoke are significant predictors for bone cancer. It is recommended to add surveillance for environmental and occupational exposures to childhood cancer patients in different oncology centers in Egypt to help tracking of environmental &occupational carcinogens.