HBE BETA-THALASSEMIA IS ASSOCIATED WITH IGA NEPHROPATHY

Thalassemia are a group of autosomal recessive inherited disorders of haemoglobin synthesis where in mutations of the-globin gene lead to various degrees of defective -chain production, an imbalance in -globin chain synthesis, ineffective erythropoiesis and anaemia. Improved survival in thalassaemic patients has led to the emergence of previously unrecognized complications, such as renal disease. Renal disease is considered the 4th cause of morbidity among patients with transfusion dependent thalassemia. IgA nephropathy (IgAN) is an immune complex-mediated glomerulonephritis, defined morphogically by the constant presence of dominant or co-dominant mesangial deposists of IgA and accompanied by avariety of histopathological lesions. It is the most common pattern of primary glomerulonephritis seen in the world and represents a significant cause of renal insufficiency in young adults. Here we report a case of 24 year old male known case of E beta thalassemia since his 8 years of age with IgA nephropathy.