CaspSites: A Database and Web Application for Experimentally Observed Human Caspase Substrates Using N‑Terminomics

CaspSites is a free-to-use database and web application
for experimentally
observed human caspase substrates using N-terminomics. It can be accessed
and used by all users at the web URL www.caspsites.org. CaspSites
stores cleavage site information identified for human caspases 1–9
in lysates and apoptotic cells, collected from their corresponding
published studies. The database can be queried, viewed, and exported
using the search page of the web application. The main parameters
offered are protein substrate, cleavage site (P4–P4′)
residues, and individual caspase data sets, which can be connected
using OR, AND, or NOT logical operators for custom user-built queries.
CaspSites will be regularly updated with new experimental findings
for understudied caspases, providing researchers insight into the
distinctive roles human caspases play in cellular processes by identifying
their target proteins in relation to each other.