Gene expression profiles in ethylene glycol-induced renal stone formation and phlorizin treatment

Nephrolithiasis is a disorder with a poor quality of life due to severe pain and no effective medication. Sodium-glucose cotransporter-2 (SGLT2) inhibitors, an anti-diabetic agent, have diuretic and anti-inflammatory effects, suggesting their benefit in treating nephrolithiasis. However, the effects of SGLT2 inhibition against renal stone formation have not been elucidated. To check gene expression profiles, microarray analysis was performed.肾结石病（Nephrolithiasis）是一类因剧烈疼痛导致生活质量低下且暂无有效治疗药物的疾病。钠-葡萄糖协同转运蛋白2（SGLT2）抑制剂作为一类抗糖尿病药物，具有利尿与抗炎作用，提示其在肾结石病治疗中具备潜在获益。然而，SGLT2抑制对肾结石形成的干预效应尚未阐明。为检测基因表达谱，本研究开展了基因微阵列（microarray）分析。