LAR1 activates NF-κB signaling pathway by binding to APOC1 mRNA and enhancing its expression: A novel mechanism underlying breast carcinogenesis

The transcriptomic changes induced by LAR1 overexpression was profiled using mRNA sequencing on LAR1-overexpressing MDA-MB-231 cells and vector controls. DEGs were defined as those with a |Log2FC| > 1.5 and a p value < 0.01. To distinguish direct targets of LAR1, we intersected these DEGs with a previously published LAR1-mRNA interactome dataset generated by RNA immunoprecipitation and microarray profiling (RIP-CHIP).