Expression data from odontogenic tumours

The aim of the study was to elucidate the cellular origin of ameloblastoma and keratocystic odontogenic tumour, neoplasms believed to arise from dental epithelial cells, by carrying out a genome-wide expression analysis. Total RNA from 27 fresh tumour samples of 15 conventional intraosseous ameloblastomas and 12 sporadic keratocystic odontogenic tumours, and 8 control samples were hybridized on Affymetrix® GeneChip Human Genome U 133 Plus 2.0 arrays. The key findings were verified by quantitative real-time PCR (QPCR) and immunohistochemistry.