Intracerebral Electric Field Magnitudes during tACS in Human In-Vivo

This dataset is used in our study entitled : "In-vivo Evidence of Electric Fields in Human Deep Cortical Structures During Transcranial Electrical Stimulation". Our main purpose was to measure the electric field in several deep brain structures during TES in humans in-vivo. In addition, we investigated the effects of TES frequencies, intensities, and montages on the intracerebral EF. Simultaneous bipolar transcranial alternating current stimulation and intracerebral recordings (SEEG) were performed in 8 drug-resistant epileptic patients. TES was applied using small high-definition (HD) electrodes. Patients gave their informed consent prior to participation (NCT03644732). Seven different tACS frequencies were tested on 1 patient (patient #0), two low intensities were applied to 6 patients (0.5 and 1mA) and 15 different montages were tested on 1 patient (Patient #7). At 1mA intensity, we found mean EF magnitudes of 0.21, 0.17 and 0.07 V.m-1 in the amygdala, hippocampus, and cingulate gyrus, respectively. An average of 0.14 ± 0.07 V.m-1 was measured in these deep brain areas. A mean global EF difference of 5% was measured in function of the frequency. The EF was correlated with the TES intensities. The TES montages that yielded the maximum EF in the amygdalae were T7-T8 and in the cingulate gyri were C3-FT10 and T7-C4. A substantial EF in deep brain structures is achievable using low intensities and small HD electrodes whatever the frequency used. EF magnitude is correlated to the stimulation intensity and dependent upon the stimulation montage. This dataset contains 8 individual anonymized MRI (nifti format) and 34 files (xls format) with (i) intracerebral electrical field (EF) magnitudes (in V/m) and (ii) 3D SEEG contact coordinates (in SCS space).