Fibrillar Nanostructure of Human Intervertebral Joints using 3D SAXS
收藏ESRF Portal2028-01-01 更新2026-04-23 收录
下载链接：
https://doi.esrf.fr/10.15151/ESRF-ES-2064095531
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资源简介：
Understanding the mechanisms underpinning musculoskeletal pathologies, like intervertebral disc (IVD) degeneration in the spine, is increasingly important worldwide. The disruption of spinal joints is related to alterations in the tissue structure and biomechanics at the micro- and nanoscale. However, measuring such changes quantitatively in intact organs remains challenging. Here, we will apply a ground-breaking multiscale synchrotron X-ray imaging technique developed by us (TomoSAXS) to measure for the first time the 3D fibrillar nanostructure in human IVD in healthy and diseased conditions, using high-energy SAXS and phase-contrast tomography. These experiments will pave the way to applying TomoSAXS to multiple clinically relevant human musculoskeletal disease conditions, leading to advances in early detection, new biomarkers, and drug treatments.
提供机构：
Queen Mary University of London, Department of Materials, School of Engineering and Materials Science Mile End Road, E1 4NS, London, GB; University Grenoble Alpes, Laboratoire d'Anatomie Des Alpe Françaises, Place Du Commandant Nal, Domaine De La Merci, 38700 La Tronche, France; Research Complex at Harwell, Rutherford Appleton Laboratory, Harwell, Ox11 0fa Didcot, United Kingdom; Queen Mary University of London, Department of Engineering, Mile End Road, E1 4ns London, United Kingdom; University College London, Department of Mechanical Engineering, Roberts Building, Torrington Place, Wc1e 7je London, United Kingdom
创建时间：
2028-01-01
