Crystal structure of bRaf in complex with inhibitor GNE-0749
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Crystal structure of bRaf in complex with inhibitor GNE-0749 Descriptor: CHLORIDE ION, N-(3,3-dimethylbutyl)-N'-{2-fluoro-5-[(5-fluoro-3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]-4-methylphenyl}urea, Non-specific serine/threonine protein kinase Authors: Yin, J, Eigenbrot, C.E, Wang, W. Deposit date: 2020-09-06 Release date: 2021-05-26 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.93 Å) Cite: Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3 H )-quinazolinone Aryl Urea pan-RAF Kinase Inhibitor. J.Med.Chem., 64, 2021
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2020-09-06
