The pre-B cell receptor (pre-BCR), consisting of the mu heavy chain (mHC) and the surrogate light chain (SLC, Vpre-B and lambda-5), plays important roles during B cell development. The formation of th
Antibody 10E8 targets the membrane-proximal external region (MPER) of HIV-1 gp41, neutralizes >97% of HIV-1 isolates, and lacks the auto-reactivity often associated with MPER-directed antibodies. The
