Specific induction of GPR15 expression in heterogeneous blood lymphocytes by smoking

Although a mucosal and cutaneous chemokine ligand for G protein –linked receptor GPR15 was recently identified, the physiological role of GPR15 remains yet elusive. In blood, in has been shown that smoking is, to date, the only specific condition leading to an increase in GPR15+ T cells. We therefore used transcriptome sequencing to describe GPR15-expressing blood T cells in more detail. Strand specific transcriptome sequencing rRNA depleted long RNA in two cell types