fmb-2021-0293_Suppltable1

Aim: To unveil a putative correlation between phage genome flexibility and virion morphogenesis yield.
Materials & methods: A deeper analysis of the mechanical properties of three Pseudomonas aeruginosa
lytic phage genomes was undertaken, together with full genome cyclizability calculations. Results &
conclusion: A putative correlation was established among phage genome flexibility, eclipse timeframe
and virion particle morphogenesis yield, with a more flexible phage genome leading to a higher burst
size and a more rigid phage genome leading to lower burst sizes. The results obtained are highly relevant
to understand the influence of the phage genome plasticity on the virion morphogenesis yield inside the
infected bacterial host cells and assumes particular relevance in the actual context of bacterial resistance
to antibiotics.