Crystal structure of the bromodomain of human BRM (SMARCA2) in complex with a SMARCA-BD binder
收藏Protein Data Bank Japan2026-01-14 更新2026-04-25 收录
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Crystal structure of the bromodomain of human BRM (SMARCA2) in complex with a SMARCA-BD binder Descriptor: (2P)-2-[(6aS,11R)-6,6a,7,8,9,10-hexahydro-5H-pyrazino[1',2':4,5]pyrazino[2,3-c]pyridazin-2-yl]phenol, Isoform Short of Probable global transcription activator SNF2L2, ZINC ION Authors: Wang, M, Dou, Y, Xu, C. Deposit date: 2024-10-02 Release date: 2025-10-01 Last modified: 2026-01-14 Method: X-RAY DIFFRACTION (3 Å) Cite: PRT3789 Is a First-in-Human SMARCA2-Selective Degrader That Induces Synthetic Lethality in SMARCA4-Mutated Cancers. Cancer Res., 86, 2026
创建时间：
2024-10-02
