Phosphine-Free and Reusable Palladium Nanoparticles-Catalyzed Domino Strategy: Synthesis of Indanone Derivatives

The
carbene migratory insertion involving a domino reaction by
highly stable, reusable, and binaphthyl-stabilized Pd-nanoparticles
(Pd-BNP) is disclosed. The reaction was catalyzed by 2 mol % of a
heterogeneous Pd-BNP catalyst under external ligand-free conditions,
and it afforded 3-aryl-substituted indanone derivatives in up to a
90% yield with exclusive E-selectivity. Furthermore,
a one-pot reaction and derivatization of indanone derivatives were
also successfully demonstrated.