Smarcb1 plays a role in fidelity of pluripotency
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下载链接：
https://www.ncbi.nlm.nih.gov/bioproject/PRJNA551543
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资源简介：
Functions of SMARCB1, one of the core subunits of BAF complexes, is not fully characterized in embryonic stem (ES) cells due to inability to establish ES cells from Smarcb1-deficient embryos. We conducted RNA-seq and ATAC-seq studies in combination with the CRISPR/Cas9-mediated genetic depletion to solve the problem. Consequently, we found that SMARCB1 plays a role in maintenance of pluripotency and differentiation fidelity of ES cells, which is potentially through regulation of chromatin landscapes.
创建时间：
2019-06-28
