Estimated enzyme activities in BMI-matched obese non-diabetic and type 2 diabetic African-American women based on plasma NEFA product to substrate ratios.^*.

*Values are reported as geometric means [ranges] if changes in geometric means between groups are significant (Mann-Whitney U-test, p<0.05 with FDR adjustment at q = 0.1). †SCD, steroyl-CoA desaturase; ELOVL2, elongase of very long chain fatty acids 2; D6D, delta 6 desaturase; SPCS, Sprecher pathway VLCPUFA chain shortening. ‡ELOVL2/D6D/SPCS has inherent dependencies on other enzymes in the very long chain fatty acid synthesis pathway including ELOVL1 and ELOVL4.