File S1 - Properly Substituted Analogues of BIX-01294 Lose Inhibition of G9a Histone Methyltransferase and Gain Selective Anti-DNA Methyltransferase 3A Activity

File S1 contains: Preparation of N-(1-benzylpiperidin-4-yl)-2-chloroquinazolin-4-amine (20). Chemical and physical data for compounds 4–11, 13–18. Table S1. Elemental analyses of compounds 4–18, 20. Table S2. Percentages of G9a inhibition by 4, 10, 13 and 14 tested in a 10-dose IC50 mode with 2-fold serial dilution starting at 400 µM. IC50 graphic data for compound 10. GLP assay. Figure S1. Binding mode of 4 (yellow sticks) in the GLP binding site (green ribbons) as predicted by Glide. Figure S2. Predicted binding mode of 4 (a) and 14 (b) in the DNMT1 X-ray structure.
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