CCR6

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

该基因编码β型趋化因子受体家族的一员，据预测其为一七次跨膜蛋白，与G蛋白偶联受体相似。该基因在未成熟的树突状细胞和记忆T细胞中优先表达。该受体的配体为巨噬细胞炎症蛋白3α（MIP-3α）。研究表明，该受体对于B谱系成熟和抗原驱动的B细胞分化至关重要，并且可能在炎症和免疫反应期间调节树突状细胞和T细胞的迁移和募集。关于该基因，已描述了编码相同蛋白质的剪接变异转录本。[由RefSeq提供，2008年7月]