First bromodomain of BRD4 in complex with ISOX-DUAL based degrader 45
收藏Protein Data Bank Japan2025-09-24 更新2026-04-19 收录
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First bromodomain of BRD4 in complex with ISOX-DUAL based degrader 45 Descriptor: 1,2-ETHANEDIOL, 1-[2-[7-[2-[4-[2-[2-[2-[4-[3-(dimethylamino)propoxy]phenyl]ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)benzimidazol-1-yl]ethyl]piperazin-1-yl]ethanoylamino]heptanoylamino]-3,3-dimethyl-butanoyl]-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Bromodomain-containing protein 4, ... Authors: Balourdas, D.I, Edmonds, A.K, Marsh, G.P, Maple, H.J, Spencer, J, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC) Deposit date: 2024-04-19 Release date: 2024-09-11 Last modified: 2025-09-24 Method: X-RAY DIFFRACTION (1.90001265923 Å) Cite: Structure-Guided Design of ISOX-DUAL-Based Degraders Targeting BRD4 and CBP/EP300: A Case of Degrader Collapse. J.Med.Chem., 68, 2025
创建时间：
2024-04-19
