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Crystal structure of the SMARCA2 bromodomain bound to a tricyclic pyrimidoindolone inhibitor (compound 17)

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Protein Data Bank Japan2025-07-02 更新2026-05-23 收录
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Crystal structure of the SMARCA2 bromodomain bound to a tricyclic pyrimidoindolone inhibitor (compound 17) Descriptor: 5-oxidanyl-2-(phenylmethyl)-1,9-dihydropyrimido[4,5-b]indol-4-one, Probable global transcription activator SNF2L2, ZINC ION Authors: Schimpl, M. Deposit date: 2025-02-28 Release date: 2025-05-14 Last modified: 2025-07-02 Method: X-RAY DIFFRACTION (2.08 Å) Cite: Discovery of Pyrimidoindolones as Novel Family VIII Bromodomain Binders. Acs Med.Chem.Lett., 16, 2025

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2025-02-28
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