Crystal Structure of Human WRN helicase with compound 26

Crystal Structure of Human WRN helicase with compound 26 Descriptor: (2R)-N-[(3R)-1,1-dioxo-1lambda~6~-thiolan-3-yl]-N-{[2-(2-hydroxypropan-2-yl)pyridin-4-yl]methyl}-2-methoxy-2-[(1M)-3,3',4'-trifluoro[1,1'-biphenyl]-4-yl]acetamide, 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Toms, A.V, Caravella, J.A, Sitnikov, N, Bartels, F, Svensson, R, Jacques O'Hagan, S, Borthwick, J, Campos, S, Yin, Y, Zhao, X, Li, L, Talbot, E, Kong, H, Freund, R.R.A, Browning, B, Genung, N.E, Carreiro, S, Brennan, D, Graves, A.P, Loh, C, Tummino, P, Edmonson, S.D, Li, D. Deposit date: 2026-01-08 Release date: 2026-05-13 Last modified: 2026-06-10 Method: X-RAY DIFFRACTION (2.58 Å) Cite: Design of Cyclic Vinyl Sulfones as WRN Covalent Inhibitors from Noncovalent Binders. J.Med.Chem., 69, 2026