Safety of Median Nerve Electrical Stimulation in Disorders of Consciousness : A Systematic Review and Meta-analysis of Randomized Controlled Trials

Fig1. Study flow diagram. No adverse reactions reported: the outcomes of interest were not measured.Fig 2. Risk of bias in the analyzed studies. (A) Risk of bias graph. (B) Risk of bias summary.Fig 3. Forest plots for seizures, increased sympathetic nerve activity, arrhythmia, nausea and vomiting. (A) Forest plot for seizure. (B) Forest plot for increased sympathetic activity. (C) Forest plot for arrhythmia. (D) Forest plot for nausea and vomiting.Fig 4. Forest plots for lethargy, pulmonary infection, intracranial hemorrhage or hematoma, and gastrointestinal bleeding. (A) Forest plot for lethargy. (B) Forest plot for pulmonary infection. (C) Forest plot for intracranial hemorrhage or hematoma. (D) Forest plot for gastrointestinal bleeding.Fig 5. Funnel plot for increased sympathetic activity.Fig 6. Sensitivity analysis, forest plot and subgroup analysis of pulmonary infection. (A) Sensitivity analysis of pulmonary infection. (B) Forest plot for pulmonary infection. (C) Sub-group analysis of the outcomes of pulmonary infection according to the intervention measures; Group 1: Routine treatment+RMNS vs Routine treatment; Group 2: Routine treatment+Acupuncture+RMNS vs Routine treatment+Acupuncture.Raw data: the data required to replicate all the research findings reported in the article.