Dehydrozingerone improves mood and memory in diabetic mice via modulating core neuroimmune genes and their associated proteins.

The purpose of this study was to see if dehydrozingerone, a structural half-analogue of curcumin, may improve mood and cognition in diabetics. We used a well-established mouse model of type 2 diabetes generated by a high-fat diet and low streptozotocin dosages. Dehydrozingerone, 50 mg/kg orally for two weeks, enhanced diabetic mice's hippocampus and prefrontal cortex-dependent mood and memory. An integrated transcriptome and proteome analysis revealed that 26 genes encoding mitochondrial energetics (Cox6), insulin resistance (Etnppl), lipid metabolism (Apod, Plin4), accelerated brain aging (Gm11639), and inflammation (Ighg2c) are differentially expressed in the diabetic mouse brain at both the mRNA and protein levels. Additionally, bioinformatic research demonstrated that these differentially expressed genes and proteins play a key role in a number of biological functions, including ion transport, calcium signaling, and cellular dysfunction and neurodegeneration.