Evaluation of CNAs in multiple myeloma tumors from Vk*MYC mice. Evaluation of CNAs in multiple myeloma tumors from Vk*MYC mice

Myeloma tumors arose in Vk*MYC mice share copy number abnormalities with multiple myeloma tumors from human patients Overall design: Genomic DNA from CD138+ magnetically selected myeloma cells harvested from aged Vk*MYC mice (original tumors) or from C57BL/6 WT mice engrafted with original Vk*MYC myeloma tumors (recipients) was hybridized to Agilent mouse whole genome 244K CGH array CL= cell line OT=original tumor R=recipient BN= bortezomib naïve BR=bortezomib resistant MM=multiple myeloma EMM= extramedullary MM NPC=normal plasma cell