A Cellular Atlas of the Down Syndrome Brain Identifies Accelerated Oligodendrocyte Precursor Cell Senescence

We performed single nucleus RNA-seq and single nucleus ATAC-seq on the cortex of Ts65Dn mouse model of Down Syndrome and euploid controls (wild types). Single nucleus RNA-seq and ATAC seq from 6 month old mouse cortex under two conditions: 1)Control (wild type), 2)Ts65Dn mouse model for Down Syndrome.本研究针对唐氏综合征Ts65Dn小鼠模型与整倍体对照（野生型）的大脑皮层，完成了单细胞核RNA测序（single nucleus RNA-seq）与单细胞核ATAC-seq（single nucleus ATAC-seq）。本次测序的样本为6月龄小鼠的大脑皮层，实验共设置两种条件：1）对照（野生型），2）唐氏综合征Ts65Dn小鼠模型。