five

We constructed 12 independent DNA molecules (3.5 kbp each) encoding the Universal Declaration of Human Rights (8.7 KB) in just 8.3 hours on a robotic platform call DNAmaker.

收藏
NIAID Data Ecosystem2026-05-10 收录
下载链接:
https://www.ncbi.nlm.nih.gov/sra/ERP186105
下载链接
链接失效反馈
官方服务:
资源简介:
Digital data storage in DNA currently relies on short single-stranded oligonucleotides (100-350 nt), which suffer from encoding constraints, stability issues, and sequencing limitations. We propose a paradigm shift: storing information in multi-kilobase double-stranded DNA molecules (1-10 kbp). The bottleneck? Manual assembly of long DNA molecules is tedious and time-intensive, requiring up to 2 days per 10 kbp construct with limited parallelisation. Here, we present DNAmaker, a fully automated in vitro platform that constructs multiple multi-kilobase DNA molecules simultaneously, dramatically reducing assembly time and enabling true scalability. As a proof of concept, we constructed 12 independent DNA molecules (3.5 kbp each) encoding the Universal Declaration of Human Rights (8.7 KB) in just 8.3 hours, demonstrating both the technical feasibility and the symbolic potential of democratising DNA-based archival storage.
创建时间:
2026-01-05
二维码
社区交流群
二维码
科研交流群
商业服务