Receptive field area_nyxnob.xlsx

<b>Abstract: </b>Patients with congenital nystagmus, unvoluntary eye movements, often have a reduced visual acuity. Some of these patients have a retinal-specific mutation in the protein nyctalopin, which is also present in the <i>Nyx^nob</i> mouse. In these mice, retinal ganglion cells (RGCs) have oscillatory activity, which leads to expanded axonal projections towards the dLGN and consequently to a desegregation of retinal projections to the brain [1]. In this study, we investigate whether the receptive fields of <i>Nyx^nob</i> RGCs have also expanded by measuring the size of their receptive fields using MEA recordings. Contrary to our expectation, relative to wild-type (WT) mice we found receptive field sizes in the <i>Nyx^nob</i> retina had not increased but instead had decreased for green-light preferring RGCs. Additionally, we also found the receptive fields of UV-light preferring RGCs are larger than green-light preferring RGCs in both WT and <i>Nyx^nob</i> mouse.