PAMPA Permeability Data

PAMPA (parallel artificial membrane permeability assay) is a commonly employed assay to evaluate drug permeability across the cellular membrane. PAMPA is a non-cell-based, low-cost and high-throughput alternative to cellular models. Although PAMPA does not model active and efflux transporters, it still provides permeability values that are useful for absorption prediction because the majority of drugs are absorbed by passive diffusion through the membrane. This dataset has two files. First file (dataset_pampa_ncats.tab) contains 2035 compounds from the National Center for Advancing Translational Sciences and the second file (drugs_pampa_ncats.tab) contains 142 approved drugs, both compound sets tested in the same PAMPA assay.

平行人工膜渗透性测定法（parallel artificial membrane permeability assay，简称PAMPA）是一类常用的药物跨细胞膜渗透性评价实验方法。PAMPA是一种非细胞依赖、低成本且高通量的细胞模型替代方案。尽管PAMPA无法模拟主动转运体与外排转运体的功能，但仍可提供可用于药物吸收预测的渗透性数值——这是因为大多数药物通过被动扩散方式透过生物膜。本数据集包含两个文件：第一个文件`dataset_pampa_ncats.tab`包含来自美国国家转化科学推进中心（National Center for Advancing Translational Sciences, NCATS）的2035种化合物；第二个文件`drugs_pampa_ncats.tab`包含142种已上市药物，两组化合物均在同一PAMPA实验中完成检测。