Text S1 - Analysing Recent Socioeconomic Trends in Coronary Heart Disease Mortality in England, 2000–2007: A Population Modelling Study

Technical appendix for the IMPACTSEC model. Contents are as follows. Section 1: Overview of the IMPACTSEC model. Table A: Population and patient data sources. Table B: Data sources for treatment uptake levels: medical and surgical treatments included in the model. Table C: Risk factors: variable definitions and source. Table D: Cumulative benefit: adjustment factors by age, sex, and IMD quintile. Table E: CHD mortality rates in 2000 and 2007 by sex and deprivation quintiles. Table F: Clinical efficacy of interventions: relative risk reductions obtained from meta-analyses, and randomised clinical trials. Table G: Case fatality rates for each patient group. Table H: Treatment uptake in 2000 and 2007. Table I: Beta coefficients for major risk factors. Table J: Relative risk values for CHD mortality: smoking, diabetes, and physical inactivity. Table K: Risk factor levels in 2000 and 2007 by sex and deprivation quintiles. Table L: Model fit by age, sex, and deprivation quintiles. Table M: Uncertainty analysis: parameter distributions, functions, and sources. Table N: Assumptions and overlap adjustments used in the IMPACTSEC Model. Table O: “Fixed gradients” for measuring risk factor change between two time points for deprivation quintiles. (DOC)