Cardiac and skeletal muscle gene expression profiles in dysferlin deficient mice

Dysferlin is expressed in skeletal and cardiac muscle. However, dysferlin deficiency, namely limb girdle muscular dystrophy 2B (LGMD2B) and Myoshi myopathy, results in skeletal muscle weakness and spares the heart. This dichotomy could be caused by differential regulation of protective mechanisms. Therefore, we compared intraindividual mRNA expression profiles between cardiac and skeletal muscle in dysferlin-deficient SJL/J mice and normal C57BL/6 mice. Keywords: parallel sample 20 chips were analyzed. They represent 4 groups of 5 replicates each. The 4 groups are cardiac (LV) and skeletal muscle of normal and dysferlin deficient mice. Tissues from normal mice are the controls in comparison to tissues of dysferlin deficient mice.