OC PK parameters estimated from Monte Carlo simulations for ferrets inoculated with influenza A or B viruses.

a Calculated by taking the 24-h dose divided by the fitted CLt.b OP dose of 1.0 mg/kg corresponds to 0.76 mg/kg, 5.0 mg/kg to 3.8 mg/kg, and 25.0 mg/kg to 19.0 mg/kg of free-base oseltamivir.AUCss24h = steady-state 24-h area under the concentration-time curve; Cmax = maximum plasma concentration; Cmin = minimum plasma concentration; CLt = first-order clearance from the central compartment; CV = coefficient of variation; OC = oseltamivir carboxylate; OP = oseltamivir phosphate; PK = pharmacokinetic; Tmax = time to reach the maximum plasma concentration.OC PK parameters estimated from Monte Carlo simulations for ferrets inoculated with influenza A or B viruses.