Worms recovered and the percentage of worm reduction after PZQ pressure.

= 20 mice were used for each group., p The initial control group is the same for the Non-selected and Selected populations.% Percentage of reduction of Selected (S) and Non-selected (N) worms obtained after treatment with PZQ at 2×100 mg/kg and 3×300 mg/kg. For each round, eggs produced by the worms that had survived the drug treatment were used to infected snails, and the cercariae obtained were used to infect a new set of mice. Mean numbers of worms recovered from treated and untreated mice after the first, sixth and seventh rounds of PZQ treatment. ≤0.05 indicates a significant difference between Selected and Non-selected parasites in the percent worm reduction upon PZQ treatment (Mann Whitney)., P SD: standard deviation.