Crystal structure of EGFR kinase domain T790M mutation in compex with HKI-272
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Crystal structure of EGFR kinase domain T790M mutation in compex with HKI-272 Descriptor: CHLORIDE ION, EPIDERMAL GROWTH FACTOR RECEPTOR, N-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide Authors: Yun, C.-H, Mengwasser, K.E, Toms, A.V, Li, Y, Woo, M.S, Greulich, H, Wong, K.-K, Meyerson, M, Eck, M.J. Deposit date: 2007-07-02 Release date: 2008-01-22 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (3.5 Å) Cite: The T790M Mutation in Egfr Kinase Causes Drug Resistance by Increasing the Affinity for ATP. Proc.Natl.Acad.Sci.USA, 105, 2008
创建时间：
2007-07-02
