Intestinal expression of ASBT determines the sclerosing cholangitis phenotype.
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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Purpose: Determine the impact of ASBT genotype on the onset and progression of liver disease, using RNA-sequencing to characterize the transcriptome of ASBT wildtype and knockout mice. We assess alterations at the gene and mechanistic-levels.Methods: mRNA profiles were generated in 45-day-old ASBT WT and KO mice (BALB/cJ background). Data were processed using the Tuxedo Pipeline, using the mm10 genome with annotations provided by Ensembl.Results: We identified 1406 differentially expressed transcripts between knockout and wildtype mice, with ontologies heavily weighted toward fibrotic and inflammatory processes, with immune cell infiltration.Conclusions: Knockout of ASBT induces increased liver injury through exposure to elevated bile acids.
提供机构：
Cincinnati Children's Hospital Medical Center
创建时间：
2022-02-20
