DNA methylation in developing country

we reviewed the effect of poor life conditions of pregnant mother living in developing countries on DNA methylation of their neonates and there making susceptible the newborn himself and also his/her upcoming generation susceptible to chronic disease. we searched PubMed, google scholar, Web of Science, Crossref for the original research conducted in developing countries to assess the effect of nutrient deficient diet, stress and pollution on neonatal DNA methylation. however due to limited research conducted in developing countries we were not able to do meta analyses but we reviewed the results of available knowledge dietary habits in most of developing countries and shortage of food causes the deficiency of essential nutrient and therefore, causes aberrant DNA methylation or the methylation of the most important genes, but more research is needed. To study the effect of pollutants, and stress there were not sufficient studies conducted in developing countries so we included the studies conducted in upper middle income countries or data of high income countries, then compared with the possible effect in developing countries, definitely the results may
be sever in developing countries.

本团队深入探讨了发展中国家孕期母亲恶劣生活条件对其新生儿DNA甲基化的影响，该影响不仅使新生儿自身易受慢性疾病的侵袭，亦使其后代面临同样的风险。为评估营养缺乏、压力与污染对新生儿DNA甲基化的影响，我们查阅了PubMed、Google Scholar、Web of Science及Crossref数据库中发展中国家进行的原始研究。然而，鉴于发展中国家相关研究的局限性，我们未能进行荟萃分析，但我们对大多数发展中国家现有的知识、饮食习惯以及食物短缺导致的必需营养素缺乏所引发的异常DNA甲基化或重要基因的甲基化情况进行了综述。鉴于发展中国家在污染物与压力影响方面的研究不足，我们纳入了中高收入国家的研究或高收入国家数据，并与发展中国家可能的影响进行了比较，结果表明，在发展中国家，该影响可能更为严重。