Transcriptome analysis of dissected muscle tissue from whole-animal Drosophila melanogaster tumour models across a time course.

Transcriptomic profiling along a time course of muscle wasting revealed a progressive deregulation of muscle structure and organisation. An array of molecular signatures were associated with this deregulation, including a perturbed ubiquitin-proteasome system, an increase in the unfolded protein response, and an increase in MAPK pathway signalling. Pooled dissected body wall muscle tissue was transcriptionally profiled in quadruplicate across a time course of muscle wasting.