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Crystal structure of the Mer kinase domain in complex with a macrocyclic inhibitor

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Protein Data Bank Japan2023-10-04 更新2026-03-21 收录
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Crystal structure of the Mer kinase domain in complex with a macrocyclic inhibitor Descriptor: (10R)-7-amino-11-chloro-12-fluoro-1-(2-hydroxyethyl)-3,10,16-trimethyl-16,17-dihydro-1H-8,4-(azeno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10H)-one, Tyrosine-protein kinase Mer Authors: Gajiwala, K.S, Ferre, R.A. Deposit date: 2016-12-07 Release date: 2017-07-26 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The Axl kinase domain in complex with a macrocyclic inhibitor offers first structural insights into an active TAM receptor kinase. J. Biol. Chem., 292, 2017
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2016-12-07
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