National Institutes of Health H3Africa African Collaborative Center for Microbiome and Genomics Research (ACCME)

The African Collaborative Center for Microbiome and Genomics Research is a multi-institutional collaborative research project. The objectives of the project are to collaborate and implement high impact integrative epidemiology and genomics research into discovery of biomarkers associated with cervical carcinogenesis. Specifically ACCME links and leverages existing funded research and program activities at the collaborating institutions to study the interaction between vaginal microbiome, host genetic factors and molecular variants of Human Papilloma Virus (HPV) to determine correlates of viral persistence in the causal pathway of cervical cancer, a major cause of preventable mortality in Nigeria and other parts of sub-Saharan Africa. This research offers several opportunities to advance understanding of cervical carcinogenesis, viral oncogenesis, new biomarker discovery and risk stratification by genotype in a cohort of African women. Sponsorship: This project is sponsored by the National Institutes of Health (NIH)]]>
Inclusion: Women At least 18 years old History of sexual intercourse No previous history of cervical abnormalities, cervical cancer or total abdominal hysterectomy Exclusion: HIV-positive Inability to give consent Male sex Unwillingness or inability to remain near clinical site for duration of study ]]>
The project started enrolling participants in November 2nd, 2014 Baseline enrollment ended on September 28th, 2016 Follow up is ongoing]]>