Cerebrovascular alterations in a mouse model of late-onset Alzheimer's disease

This collection of datasets is from three cohorts of mice. Mice in cohort #1 had resting-state cerebral blood flow (CBF) measured with laser speckle imaging (LSI) across different age groups (12, 18, and 22 – 27 m.o.) in WT, hAβ-KI, and 3xTg-AD mice. Mice in cohort #2 utilized WT and hAβ-KI mice at 23 – 25 m.o. and had bulk RNA-sequencing performed to examine transcriptomics. Mice in cohort #3 utilized WT and hAβ-KI mice at 24 m.o. to examine cerebrovascular structure and neurovascular coupling (NVC). Datasets from cohorts #1 and #3 include the output data (e.g., resting-state CBF), mouse genotype, age group, and sex. Datasets from cohort #2 include results from differential gene expression analysis between genotypes and gene set enrichment analysis (GSEA) as .tsv files., , # Cerebrovascular alterations in a mouse model of late-onset Alzheimer's disease

Dataset DOI: [10.5061/dryad.dv41ns295](10.5061/dryad.dv41ns295)

## Description of the data and file structure

This collection of datasets is from three cohorts of mice. Mice in cohort #1 had resting-state cerebral blood flow (CBF) measured with laser speckle imaging (LSI) across different age groups (12, 18, and 22 – 27 m.o.) in WT, hAβ-KI, and 3xTg-AD mice. Mice in cohort #2 utilized WT and hAβ-KI mice at 23 – 25 m.o. and had bulk RNA-sequencing performed to examine transcriptomics. Mice in cohort #3 utilized WT and hAβ-KI mice at 24 m.o. to examine cerebrovascular structure and neurovascular coupling (NVC). Datasets from cohorts #1 and #3 include the output data (e.g., resting-state CBF), mouse genotype, age group, and sex. Datasets from cohort #2 include results from differential gene expression analysis between genotypes and gene set enrichment analysis (GSEA) as .tsv files.

### Files and variables
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