Data for: An accurate and rapidly calibrating speech neuroprosthesis

Brain-computer interfaces can enable communication for people with paralysis by transforming cortical activity associated with attempted speech into text on a computer screen. Communication with brain-computer interfaces has been restricted by extensive training requirements and limited accuracy. A 45-year-old man with amyotrophic lateral sclerosis (ALS) with tetraparesis and severe dysarthria underwent surgical implantation of four microelectrode arrays into his left ventral precentral gyrus 5 years after the onset of the illness; these arrays recorded neural activity from 256 intracortical electrodes. We report the results of decoding his cortical neural activity as he attempted to speak in both prompted and unstructured conversational contexts. Decoded words were displayed on a screen and then vocalized with the use of text-to-speech software designed to sound like his pre-ALS voice. On the first day of use (25 days after surgery), the neuroprosthesis achieved 99.6% accuracy with a ..., , , # Data for: An accurate and rapidly calibrating speech neuroprosthesis

Dryad DOI: https://doi.org/10.5061/dryad.dncjsxm85

Nicholas S. Card, Maitreyee Wairagkar, Carrina Iacobacci, Xianda Hou, Tyler Singer-Clark, Francis R. Willett, Erin M. Kunz, Chaofei Fan, Maryam Vahdati Nia, Darrel R. Deo, Aparna Srinivasan, Eun Young Choi, Matthew F. Glasser, Leigh R. Hochberg, Jaimie M. Henderson, Kiarash Shahlaie, Sergey D. Stavisky*, and David M. Brandman*.

* \"*\" denotes co-senior authors

## Overview

This repository contains the data necessary to reproduce the results of the paper \"*An Accurate and Rapidly Calibrating Speech Neuroprosthesis*\" by Card et al. (2024), *N Eng J Med*.

The code is written primarily in Python and is hosted on [GitHub](https://github.com/Neuroprosthetics-Lab/nejm-brain-to-text).

The data can be downloaded from this Dryad repository. Please download this data and place it in the `data` directory of the GitHub code. All included data has been anonymized and does not...,