STROMAL EXPRESSION OF CD10 IN BREAST CANCER- A NEW PROGNOSTIC MARKER

• Breast cancer is the most common cause of cancer death among women worldwide and is essential to diagnose and treatment early.
• Novel stromal markers are now emerging to aid in predicting the prognosis and treatment of malignant breast lesions.
• CD10 is a membrane-bound metalloprotease that cleaves protein components of extracellular matrix, playing a role in tumor progression.
• CD10 is expressed on the surface of a variety of normal cells including breast myoepithelial cells.
• Stromal expression of CD10 is associated with poor prognosis in breast cancer.
• Routine CD10 staining may help in planning the treatment for breast cancer patients. Also, CD10 can be used as a target for the development of novel therapies.