five

single-cell RNA-Seq of colorectal cancer patient samples

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NIAID Data Ecosystem2026-03-14 收录
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https://www.omicsdi.org/dataset/ega/EGAS00001006665
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We describe in a prospective cohort a novel CD8+ T effector memory population, which is characterized by high levels of Granzyme K (GZMK high CD8+ TEM) and correlated with CD15 high tumor infiltrating neutrophils. In this context, we performed single-cell RNA-Seq analysis on matched tumor and non-tumor adjacent unsorted tissues to define a gene signature of GZMK high CD8+ TEM. This was associated with worse prognosis on a larger independent cohort of CRC patients and of lung cancer (TCGA).EGA study EGAS00001006665
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2022-10-25
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