Results of single-trait MR, heterogeneity analyses, and directionality analyses with pruned lipid IV sets.

Lipid summary statistics were from MVP, and MR tests used the IVW method. Heterogeneity analyses used Cochran's Q, and directionality analyses used the Steiger test. Exposure: lipid trait used as the exposure; N_SNPs: number of genetic instruments included in analysis; OR: OR of MR test; CI_95_L: lower bound of 95% CI; CI_95_U: upper bound of 95% CI; MR_P: P-value of MR test; Q: Cochran’s Q statistic; Q_df: degrees of freedom in Cochran’s Q test; Q_Pval: P-value of Cochran’s Q test; SNP_r2_exposure: estimated variance in lipid trait explained by genetic instruments; SNP_r2_outcome: estimated variance in breast cancer risk explained by genetic instruments; Steiger_pval: P-value of Steiger test inference of causal direction; correct_causal_direction: logical, is the causal direction inferred by the Steiger test in the correct direction. CI, confidence interval; HDL, high-density lipoprotein; IV, instrumental variable; IVW, inverse-variance weighted; LDL, low-density lipoprotein; MR, Mendelian randomization; MVP, Million Veteran Program; OR, odds ratio; TC, total cholesterol; TG, triglyceride.
(XLSX)