Base-Mediated Regio- and Stereoselective Intermolecular Addition of Alkynes to N-Heterocycles
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https://figshare.com/articles/dataset/Base_Mediated_Regio_and_Stereoselective_Intermolecular_Addition_of_Alkynes_to_i_N_i_Heterocycles/2672860
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The regio- and stereoselective addition of N-heterocycles to alkynes using KOH is reported. Formation of (Z)-isomers and their conversion to (E)-products were found to be dependent upon time as well as the choice of base. Selective attack of N-heterocycles on a more electrophilic alkynyl carbon was supported by DFT calculations, and the stereochemistry of the products was established by X-ray crystallographic studies and intramolecular cyclization of ortho-haloalkynes in indolo-[2,1-a]isoquinolines.
创建时间：
2016-02-23
