DNA Damage Response Dysregulation by Antisense Oligonucleotides

NIAID Data Ecosystem2026-05-10 收录

DNA损伤应答

反义寡核苷酸

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP674104 数据链接链接失效反馈

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资源简介：

Transcriptomic sequences used in 'DNA Damage Response Dysregulation by Antisense Oligonucleotides'.

创建时间：

2026-02-05

Phosphorylation of murine p53 at Ser-18 regulates the p53 responses to DNA damage

磷酸化调控

DNA损伤应答

Ser-15 of human p53 (corresponding to Ser-18 of mouse p53) is phosphorylated by ataxia-telangiectasia mutated (ATM) family kinases in response to ionizing radiation (IR) and UV light. To determine the

PubMed Central2000-10-17 更新40

The intrinsically disordered region of the E3 ubiquitin ligaseTRIP12 induces the formation of chromatin condensates and interferes withDNA damage response.

染色质相分离

DNA损伤应答

Chromatin compaction is crucial for the expression and the integrity of the genome. We previously showed that the nuclear HECT-type E3 ubiquitin ligase TRIP12 (Thyroid hormone Receptor Interacting Pro

NIAID Data Ecosystem20

Effects on DDR by small molecule inhibitors targeting acetylation signaling.

DNA损伤应答

乙酰化信号通路抑制剂

Effects on DDR by small molecule inhibitors targeting acetylation signaling.

NIAID Data Ecosystem10

Gene expression profiling of PBL in response to ionising radiation and modeled microgravity

辐射生物学

DNA损伤应答

BACKGROUND: Ionizing radiation (IR) can be extremely harmful for human cells since an improper DNA-damage response (DDR) to IR can contribute to carcinogenesis initiation. Perturbations in DDR pathway

NIAID Data Ecosystem40

Effects of ARL4C ASO on an orthotopic transplantation model

胰腺癌原位移植模型

反义寡核苷酸

To compare molecular characteristics between pancreatic tumors from mice injected with control antisense oligonucleotide (ASO) and ARL4C ASO, RNA sequence analysis was performed for primary tumors gen

NIAID Data Ecosystem20

DNA Damage Response Dysregulation by Antisense Oligonucleotides

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