Structural basis of KIT activation by oncogenic mutations in the extracellular region reveals a zipper-like mechanism for ligand-dependent or oncogenic receptor tyrosine kinase activation
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Structural basis of KIT activation by oncogenic mutations in the extracellular region reveals a zipper-like mechanism for ligand-dependent or oncogenic receptor tyrosine kinase activation Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, COBALT (II) ION, Mast/stem cell growth factor receptor Kit Authors: Reshetnyak, A.V, Boggon, T.J, Lax, I, Schlessinger, J. Deposit date: 2014-05-03 Release date: 2015-03-18 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.4 Å) Cite: The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer. Mol.Cell, 57, 2015
创建时间：
2014-05-03
