BCDX2 complex stabilizes RAD51 filament

The BCDX2 complex, composed of RAD51 paralogs RAD51B, RAD51C, RAD51D and XRCC2, preferentially binds at the ends of 3' overhanging ssDNA created by resection of DNA double-strand breaks (DSBs). The BCDX2 complex stabilizes nucleoprotein filaments formed by BRCA2-mediated RAD51 loading onto ssDNA (Masson et al. 2001, Chun et al. 2013). The BCDX2 complex may act by inhibiting displacement of RAD51 by BLM helicase (Amunugama et al. 2013).

BCDX2复合体，由RAD51同源物RAD51B、RAD51C、RAD51D和XRCC2组成，优先结合于由DNA双链断裂（DSBs）切除产生的3'末端突出单链DNA（ssDNA）。BCDX2复合体通过BRCA2介导的RAD51在ssDNA上的装载，稳定由之形成的核蛋白纤维（Masson等，2001年，Chun等，2013年）。BCDX2复合体可能通过抑制BLM解旋酶对RAD51的置换作用而发挥作用（Amunugama等，2013年）。