Draft genomes of the algae Tisochrysis lutea strains

in a context of human population increase and depletion of terrestrial resources, exploitation of microalgae is an ecofriendly alternative path for the future. currently, microalgae are used in many areas domain like food, feed, bio-remediation, health industry and third generation biofuels. yet, until now, all cultivated microalgae strains are derived directly from their natural environment. one way of improving productivity is the acquisition of selected algae strains with improved capabilities. in this study, we show that the intra-strain diversity in microalgae can be exploited to produce improved strains. an improved strain with high neutral lipid productivity was obtained, which could be used, for example, for feed or bio-fuels applications. this study also shows the necessity to study and exploit biodiversity within microalgae specie. in addition, we obtained drafts genomes and phenotypic comparisons between the wild-type and the improved clonal strains. these results reflect the origin of intra-strain diversity and microalgae adaptive capacity. the clonal strain selected accumulates more lipids, at the expense of carbohydrates. the numerous patterns of transposable element activity suggest that it is the main driver of this adaptation.

在人类人口增长和陆地资源枯竭的背景下，微藻的利用成为了一条环保的未来替代途径。目前，微藻在诸如食品、饲料、生物修复、健康产业以及第三代生物燃料等多个领域得到了广泛应用。然而，迄今为止，所有培育的微藻菌株均直接源自其自然环境。提高生产力的一个途径是获取具有改进性能的精选藻株。在本研究中，我们展示了微藻菌株内部的多样性可以被用来培育改良菌株。我们获得了一种具有高中性脂质生产力的改良菌株，该菌株可用于饲料或生物燃料等应用。本研究还强调了研究并利用微藻物种内部生物多样性的必要性。此外，我们还获得了野生型和改良克隆菌株的基因组草图以及表型比较。这些结果反映了菌株内部多样性以及微藻的适应性来源。所选克隆菌株在积累更多脂质的同时，以碳水化合物为代价。可移动元件活动的多种模式表明，它是这一适应性演变的主要驱动因素。