Effect of estrogen receptor alpha (ERα) signaling in dendritic cells in modulating autoimmune disease phenotype in animal model of Multiple Sclerosis
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE215238
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ERα has been shown to have a protective effect.We found that ERα deficiency in dendritic cells (DCs) of mice induced a phenotype “switch” in EAE, defined by severe neurodegeneration and resistance to interferon beta. Diminished ERα signaling in DCs generate neurotoxic effector CD4+ T cells. Gene expression analysis of RNAseq data from CD4+T cells isolated from WT and ERa KO mice with EAE
创建时间：
2023-02-21
